论文部分内容阅读
作者发现,大戟科巴豆属植物Croton sublyrathusKutz茎的丙酮提取物有抗消化性溃疡的活性物质。用抗溃疡活性作指导,从丙酮提取物中分离到抗利血平诱导小鼠溃疡的有效成份18-羟基牻牛儿基牻牛儿醇和抗大白鼠Shay溃疡有效的一些新的呋喃二萜。本文报道后者的结构测定。81.5公斤植物茎的粉用丙酮热提三次,提取物溶于101 80%甲醇中,用正己烷洗涤,然后经浓缩后再在激烈搅拌下注入40l苯中,苯液用碳酸氢钠溶液洗涤后蒸干,残留物用醚提取,醚溶部分中分到18-羟基牻牛儿基牻牛儿醇。醚不溶部分用硅胶反复柱层析,分
The authors found that the acetone extract of Croton sublyrathus Kutz stem of the genus Euphorbiaceae has peptic ulcer activity. Guided by anti-ulcer activity, isolated from acetone extract anti-reserpine-induced ulcer in mice active ingredient 18-hydroxy geranylgeraniol and anti-mouse Shay ulcer effective some new furan diterpene. This article reports the structural determination of the latter. 81.5 kg of plant stem powder three times with acetone heat extraction, the extract was dissolved in 101 80% methanol, washed with n-hexane, then concentrated under vigorous stirring and then injected into 40l benzene, benzene solution was washed with sodium bicarbonate solution Evaporated to dryness and the residue extracted with ether. The ether-soluble fraction was assigned to 18-hydroxy geranyl geraniol. The ether-insoluble part was subjected to repeated column chromatography on silica gel