Single-cell transcriptional profile of ACE2 in healthy and failing human hearts

• 作 者: Yitian Zhou Yongfa Huang Xiaomin Song Xiaoxiao Guo Junling Pang Jing Wang Shuyang Zhang Chen Wang
• 机 构: State Key Laboratory of Medical Molecular Biology, Institute of Basic Medical Sciences, Chinese Acad
• 出 处: 中国科学：生命科学（英文版）
• 发表日期: 2021年4期

Dear Editor,rnThe coronavirus disease 2019 (COVID-19) pandemic, which is caused by SARS-CoV-2, has gained serious attention from medical practitioners around the world in the past few months.Approximately 20％ of critically ill COVID-19 patients were reported to have suffered myocardial injury.The specific mechanism of this pathology requires further investigation (Yang et al., 2020).It was reported that SARS-CoV-2 invades alveolar epithelial cells via the angiotensin converting enzyme (ACE2) cell receptor in the lungs, but whether cardiomyocytes can be directly infected with SARS-CoV-2 via ACE2 remains controversial (Zhou et al., 2020).The rapid development of single-cell RNA sequencing (scRNA-seq) in recent years has enabled us to analyze the transcriptome with a single-cell resolution.In this study, we analyzed the scRNA-seq data from human hearts in the Gene Expression Omnibus public database to investigate the expression profile of ACE2 and the expression profiles of other genes in different types of human heart cells.