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放射治疗是头颈部恶性肿瘤的主要治疗方法之一,由于头颈部解剖关系复杂,使恶性肿瘤细胞被杀伤的同时,邻近涎腺组织也受到损伤,超过一定剂量时往往会引起放射性涎腺炎的发生,导致涎液分泌减少,继而使患者口腔黏膜及牙齿等组织器官发生一系列并发症,影响咀嚼、吞咽和语言等各项功能,严重影响患者生活质量。因此,对涎腺放射损伤机制的研究一直是国内外学者关注的热点,而干细胞治疗方式具有有效减轻及潜在治疗涎腺放射损伤的
Radiation therapy is one of the main treatment of head and neck cancer. Due to the complex anatomy of the head and neck, the malignant tumor cells are killed and adjacent salivary glands are also damaged. Radiation salivary glands are usually caused when the dose exceeds a certain dose Inflammation occurs, leading to decreased secretion of salivary fluid, which in turn leads to a series of complications such as oral mucosa, teeth and other tissues and organs, affecting various functions such as chewing, swallowing and language, which seriously affect the quality of life of patients. Therefore, the study on the mechanism of radiation injury in salivary glands has been a hot topic both at home and abroad, and stem cell therapy has the potential to reduce and potentially treat salivary gland radiation injury