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用PCR方法检测东南亚缺失型α-地贫1--SEA/αα基因的方法对6例α-地贫家系进行胎儿产前检测,结果:1例为Bart水肿胎儿(死胎),1例为东南亚缺失型α-地贫1基因携带者,其余4例为α-地贫2携带者或正常胎儿。该法简洁、易行、准确性高,为α-地贫早期胎儿诊断及α基因的检测提供一种新方法。
Detection of 1-SEA / αα Gene in Deletion-type A-Thalassemia in Southeast Asia by PCR Method Six cases of α-thalassemia pedigree were tested prenatally. Results: 1 case was Bart edema (stillbirth) and 1 case was Southeast Asia Lack of α-thalassemia 1 gene carriers, and the remaining 4 cases of α-thalassemia 2 carriers or normal fetuses. The method is concise, easy and accurate. It provides a new method for the diagnosis of fetal α-thalassemia and detection of α-thalassemia.