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Objective To investigate the differences of endocrine and metabolic characteristics in PCOS women among different subtypes.Methods A total of 249 PCOS women were classified into 4 subtypes by Rotterdam criteria:hyperandrogenism (HA) and oligo-ovulation/anovulation (0) and PCO ultrasonography (P) (HA+O+P,group A,111 women); HA+O (group B,9 women); HA+P (group C,22 women) and O+P (group D,107 women).Another 110 infertile women with tubal defects constituted a control group.Endocrine and metabolic characteristics were compared among the 5 groups.PCOS women were then reclassified into 2 groups,according to whether they have hyperandrogenism or not.Endocrine and metabolic characteristics were then compared again.Results The levels of androstenedione (A),testosterone (T) and LH/FSH were the highest in group A and group C,secondly in group D,the lowest was in control group.A,T and LH/FSH were the highest in hyperandrogenism group,secondly in nonhyperandrogenism group,whereas the control was the lowest.Menstrual cycle ana BMI correlated with glucose and lipid metabolism but showed no correlation with T and A.Hyperandrogenism group had higher fasting glucose (FG),glucose at 60 min (G60) and glucose levels under the curve (GLUAUC) and lower disposition index (DI) than non-hyperandrogenism group,however,menstrual cycle,BMI and the lipid indicators had no difference.Conclusion Hyperandrogenism is an important characteristic in PCOS women.Thus it might be used to classify PCOS into 2 subgroups.Hyperandrogenism and lipid disorders for the formation of PCOS often coexist but each has individual pathogenesis.