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目的:探讨C反应蛋白(CRP)在结直肠癌患者中的表达及与预后的关系。方法:采用免疫速率散射比浊法检测血清CRP,并与健康对照组进行比较,分析CRP与临床病理分期之间的关系,评价术前、术后CRP表达与预后的关系。结果:研究组术前CRP为(28.64±7.15)mg/L,术后降低为(7.83±1.03)mg/L,差异有统计学意义(P<0.05),都高于对照组的(1.13±0.28)mg/L,差异有统计学意义(P<0.05)。CRP表达与年龄和性别中的表达差异无统计学意义(P>0.05),与T、N、M分期和分化程度有关(P<0.05)。术前高、低CRP组的5年生存率分别为79.17%和95.24%,差异有统计学意义(P<0.05);术后高、低CRP组的5年生存率分别为85.00%和88.00%,差异无统计学意义(P>0.05)。结论:结直肠癌与炎症反应密切相关,CRP在其发生、发展中发挥着重要作用,术前CRP水平对疾病的预后具有一定的预测价值。
Objective: To investigate the expression of C-reactive protein (CRP) in patients with colorectal cancer and its relationship with prognosis. Methods: Serum CRP was detected by immunostaining nephelometry. The relationship between CRP and clinical stage was analyzed. The relationship between CRP expression and prognosis was evaluated. Results: The preoperative CRP was (28.64 ± 7.15) mg / L in the study group and (7.83 ± 1.03) mg / L in the postoperative group, with a significant difference (P <0.05) 0.28) mg / L, the difference was statistically significant (P <0.05). There was no significant difference in the expression of CRP between age, sex and gender (P> 0.05), but related to the stages and differentiation of T, N, M (P <0.05). The 5-year survival rates of preoperative high and low CRP groups were 79.17% and 95.24%, respectively, with significant difference (P <0.05). The 5-year survival rates of high and low CRP groups were 85.00% and 88.00% , The difference was not statistically significant (P> 0.05). Conclusion: Colorectal cancer is closely related to inflammatory reaction. CRP plays an important role in its occurrence and development. Preoperative CRP level has certain predictive value for the prognosis of the disease.