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为探讨慢性肾功能衰竭（CRF）及尿毒症肺（UL）患者血浆内皮素-1（ET-1）、心钠素（ANP）含量改变的规律。采用放射免疫分析方法检测正常对照组、CRF及UL组及后两组血液透析前后EL-1及ANP，同时测定血清肌酐（Cr）。结果：①UL组ET-1及ANP均显著高于CRF组（P＜0．01），ET-1与病程呈正相关（r=0.652，P＜0．001），与肌酐清除率（Ccr）呈负相关（r=-0．486，P＜0．05）；③两组透析后血浆ET-1均显著升高，且UL组更为明显（P＜0．01）。提示见-1及ANP与尿毒症肺有明星相关，可作为尿毒症肺诊断参考指标之一。
To investigate the changes of plasma endothelin-1 (ET-1) and atrial natriuretic peptide (ANP) in patients with chronic renal failure (CRF) and uremia lung (UL) Radioimmunoassay was used to detect EL-1 and ANP before and after hemodialysis in CRF, UL group and UL group, and serum creatinine (Cr) was measured simultaneously. Results: ① The ET-1 and ANP levels in the UL group were significantly higher than those in the CRF group (P <0.01). ET-1 was positively correlated with the course of the disease (r = 0.652, P <0.001) (R = -0.486, P <0.05). ③ The levels of plasma ET-1 were significantly increased after dialysis in both groups, and the UL group was more obvious (P <0.01). Suggest that see -1 and ANP with uremic lung have star-related, can be used as a reference indicator of uremic lung diagnosis.