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目的:了解宿州市2013年手足口病的病原型别和分布特征,为制订手足口病的防治策略提供依据。方法:采集295例临床诊断手足口病例的生物标本,采用Real-time RT-PCR方法检测肠道病毒71型(EV71)、柯萨奇病毒A组16型(CoxA16)及柯萨奇病毒A组6型CoxA6)的特异性核酸。结果:295例手足口病患者标本,肠道病毒核酸总阳性数94例,总阳性率31.9%,EV71阳性67份,阳性率22.7%,CoxA16阳性数0份,阳性率0%,CoxA6阳性数13份,阳性率4.4%,其他肠道病毒13份,阳性率4.4%。男女比为1.5∶1,男女阳性率分别为32.4%和31.1%,差异无统计学意义(χ2=0.055,P>0.05)。结论:2013年宿州市手足口病流行的病原体优势株为EV71,同时伴有CoxA6和其他肠道病毒感染。发病以5岁以下婴幼儿为主(97.9%),无性别差异,分布无地域差别。全年均可发病。
Objective: To understand the etiology and distribution of hand, foot and mouth disease in Suzhou in 2013, and to provide the basis for the prevention and control strategy of hand-foot-mouth disease. Methods: A total of 295 cases of hand-foot-mouth disease were collected. Real-time RT-PCR was used to detect enterovirus 71 (EV71), CoxA16 and Coxsackievirus A Type 6 CoxA6). Results: 295 cases of hand-foot-mouth disease patients and 94 cases of enterovirus nucleic acid were positive, the total positive rate was 31.9%, the positive rate of EV71 was 67, the positive rate was 22.7%, and the positive rate was 0%. The positive rate of CoxA6 13, the positive rate of 4.4%, 13 other enterovirus, the positive rate of 4.4%. The male-female ratio was 1.5: 1. The positive rates of male and female were 32.4% and 31.1% respectively, with no significant difference (χ2 = 0.055, P> 0.05). Conclusion: The predominant pathogen of hand, foot and mouth disease in Suzhou City was EV71 in 2013 with CoxA6 and other enterovirus infections. The incidence of infants and children under the age of 5 mainly (97.9%), no gender differences, geographical distribution without geographical differences. All year disease.