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目的观察盐酸法舒地尔治疗急性脑梗死的疗效。方法选取急性脑梗死患者96例,随机分为治疗组50例,对照组46例。在基础治疗上,治疗组经静脉给予法舒地尔30mg,2次/d,同时使用舒血宁注射液10mL,2次/d;对照组给予丁咯地尔,50mg,2次/d,同时使用舒血宁注射液10mL,2次/d。进行治疗前、后临床神经功能缺损程度评分,观察用药期间不良反应。结果对于急性脑梗死,两种药物对上下肢运动障碍、语言障碍及总神经功能缺损改善均有效,但无显著性差异(P>0.05)。两组均未发现不良反应。结论急性脑梗死应用法舒地尔能有效改善患者神经功能缺损,且无严重不良反应。盐酸法舒地尔是一种脑梗死治疗的安全有效药物。
Objective To observe the efficacy of fasudil hydrochloride in the treatment of acute cerebral infarction. Methods A total of 96 patients with acute cerebral infarction were randomly divided into treatment group (n = 50) and control group (n = 46). In the basic treatment, the treatment group was fasudil intravenously 30mg, 2 times / d, while Shuxuening injection 10mL, 2 times / d; control group buflomedil, 50mg, 2 times / d, Shuxuening injection while using 10mL, 2 times / d. Before and after treatment, the degree of clinical neurological impairment was observed, and the adverse reactions were observed during the treatment. Results For acute cerebral infarction, the two drugs were effective in improving upper and lower extremity dyskinesia, speech impairment and general neurological deficit, but no significant difference (P> 0.05). No adverse reactions were found in both groups. Conclusion Application of fasudil in acute cerebral infarction can effectively improve the neurological deficit in patients without serious adverse reactions. Fasudil hydrochloride is a safe and effective drug for the treatment of cerebral infarction.