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本文对339例不同孕期妇女、胎儿和不同年龄组的健康人进行C_4、C_3和Ig含量检测,提示孕妇C_4和C_3含量无明显变化,但抗体合成低下,IgA含量在各孕期均降低,IgG仅中孕和晚孕降低,可能主要与甲胎蛋白和绒毛膜促性腺激素升高而受抑有关。胎儿除8个月以上者IgG含量与母体相似外,C_4、C_3和IgM、IgA含量均明显低于孕妇,提示胎盘能传递IgG,且随胎龄增长而增多。胚胎期补体合成比Ig更早,C_4、C_3和IgM、IgG含量从胎儿起,IgA从新生儿起逐期增高。老年人IgG、C_4和C_3无明显变化,但IgM降低,提示老年人抗体合成反常,与调节外来抗原刺激反应的T抑制细胞活性增强,而调节自身抗体产生的T抑制细胞活性减弱有关。提示补体量是相对稳定的,并不随孕期抗体合成抑制和老年抗体合成反常而波动。
In this paper, C_4, C_3 and Ig contents of 339 pregnant women, fetuses and different age groups were detected, suggesting that there was no significant change in the content of C_4 and C_3 in pregnant women, but the antibody synthesis was low, IgA content decreased in each pregnancy, IgG only Pregnancy and late pregnancy decreased, may be mainly related to the increase of a-fetoprotein and chorionic gonadotropin. Except for the fetus with IgG content similar to that of maternal for more than 8 months, the contents of C_4, C_3, IgM and IgA were significantly lower than those of pregnant women, suggesting that the placenta could transmit IgG and increase with the increase of gestational age. Embryonic complement synthesis earlier than Ig, C_4, C_3 and IgM, IgG content from the fetus, IgA from the newborn increased gradually. There was no significant change of IgG, C_4 and C_3 in the elderly, but the decrease of IgM, which suggested that the antibody synthesis in the elderly was abnormal, which was related to the increase of T-suppressor cells regulating the stimulation of foreign antigens and the decrease of T-suppressor cells produced by autoantibodies. Suggesting that the amount of complement is relatively stable, does not with the synthesis of antibodies during pregnancy inhibition and abnormal synthesis of elderly volatile.