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目的 了解长期家庭氧疗 (LTOT)对缓解期合并慢性Ⅱ型呼吸衰竭的慢性阻塞性肺疾病(COPD)病人预后及生活质量的影响。方法 对 52例缓解期并慢性Ⅱ型呼吸衰竭的COPD病人根据其经济状况分为长期家庭氧疗组和非氧疗组 ,氧疗组每日吸氧时间≥ 1 5h ,非氧疗组未行氧疗。对两组病人进行连续 3年随访 ,每半年复查血常规、血气分析、肺功能。结果 氧疗组半年、1年后PaO2 及SaO2 显著高于非氧疗组 ,血红蛋白、红细胞压积显著低于非氧疗组 ;氧疗组每年平均住院次数显著低于非氧疗组 ;氧疗组 3年的病死率显著低于非氧疗组。结论 长期家庭氧疗对COPD缓解期并慢性Ⅱ型呼吸衰竭的病人能显著降低远期的病死率 ,提高病人的生活质量
Objective To investigate the effect of long-term home oxygen therapy (LTOT) on prognosis and quality of life in patients with chronic obstructive pulmonary disease (COPD) with remission type Ⅱ respiratory failure. Methods Fifty-two COPD patients with remission and chronic type II respiratory failure were divided into long-term family oxygen therapy group and non-oxygen therapy group according to their economic status. Oxygen therapy group had oxygen inhalation time ≥15 hours per day and non-oxygen therapy group did not Oxygen therapy. Two groups of patients for 3 consecutive years of follow-up, review the blood routine every six months, blood gas analysis, pulmonary function. Results In the oxygen therapy group, the PaO2 and SaO2 values were significantly higher than those in the non-oxygen therapy group after one and half year, and hemoglobin and hematocrit were significantly lower than those in the non-oxygen therapy group. The average number of hospitalization in the oxygen therapy group was significantly lower than that in the non-oxygen therapy group. Three-year mortality was significantly lower than the non-oxygen treatment group. Conclusion Long-term home oxygen therapy can significantly reduce the long-term mortality and improve the quality of life of patients with COPD remission and chronic type II respiratory failure