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【目的】探讨胎盘、胎膜细胞凋亡与分娩动因的关系。【方法】采用TUNEL法和电镜法检测妊娠晚期不同产程的胎盘、胎膜组织中的细胞凋亡情况。【结果】羊膜上皮细胞凋亡指数 (AI)、绒毛膜滋养细胞AI、胎盘绒毛滋养细胞AI与蜕膜细胞AI在未临产组、潜伏期组、活跃期组与顺产组之间差异均有极显著性 (P <0 0 1) ,且羊膜上皮细胞AI、绒毛膜滋养细胞AI、胎盘绒毛滋养细胞AI与蜕膜细胞AI均随未临产组、潜伏期组、活跃期组、顺产组的顺序增大。【结论】胎盘、胎膜组织中细胞凋亡的变化与分娩发动和产程进展有关
【Objective】 To investigate the relationship between the apoptosis of placenta and fetal membranes and the motivation of childbirth. 【Methods】 TUNEL and electron microscopy were used to detect the apoptosis of placenta and fetal membranes in different stages of pregnancy. 【Results】 AI in amniotic epithelial cells, AI in chorionic villi, AI in placental trophoblasts and AI in decidual cells were significantly different between non-productive group, latent group, active group and non-pregnant group (P <0.01). AI of amniotic epithelial cells, AI of chorionic trophoblast, AI of placental trophoblastic cells and AI of decidual cells increased with the order of non-labor group, latent group, active group and cesarean section . 【Conclusion】 The changes of apoptosis in placenta and fetal membranes are related to the onset of labor and the progress of labor