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目的探讨血清Fractalkine(FKN)和高敏C反应蛋白(hsC-RP)与DR的关系。方法选取2014年3月至2015年3月于我科住院的126例T2DM患者,根据眼底荧光造影,分为单纯糖尿病(NDR)组、非增殖期DR(NPDR)组和增殖期DR(PDR)组,同时,另选取40名健康体检者作为正常对照(NC)组。测定各组血清FKN和hsC-RP水平,并分析FKN与hsC-RP的相关性。结果 NDR、NPDR、和PDR组血清FKN水平[(0.68±0.08)vs(0.75±0.11)vs(0.92-0.17)vs(0.59±0.06)ng/ml]和hsCRP水平[(3.81±1.08)vs(5.87±2.24)vs(8.03±3.06)vs(1.74±0.53)mg/L]均高于NC组,且随DR的加重逐渐升高(P<0.05)。血清FKN与hsC-RP呈正相关(r=0.486,P%0.01)。FKN、hsC-RP、HbA_1c、LDL-C是DR的危险因素。结论血清FKN和hsC-RP是DR的危险因素,可能参与DR的发生发展。
Objective To investigate the relationship between serum Fractalkine (FKN) and high-sensitivity C-reactive protein (hsC-RP) and DR. Methods Totally 126 T2DM patients hospitalized in our department from March 2014 to March 2015 were divided into NDM group, NPDR group and PDR group according to fundus fluorescein angiography. At the same time, another 40 healthy subjects were selected as normal control (NC) group. The levels of serum FKN and hsC-RP in each group were determined, and the correlation between FKN and hsC-RP was analyzed. Results The levels of serum FKN in NDR, NPDR and PDR group were significantly higher than those in control group [(0.68 ± 0.08) vs (0.75 ± 0.11) vs (0.92-0.17) vs (0.59 ± 0.06) ng / ml and hsCRP 5.87 ± 2.24 vs 8.03 ± 3.06 vs 1.74 ± 0.53 mg / L, respectively, which were higher than those in NC group (P <0.05). Serum FKN was positively correlated with hsC-RP (r = 0.486, P% 0.01). FKN, hsC-RP, HbA_1c, LDL-C are risk factors for DR. Conclusions Serum FKN and hsC-RP are risk factors for DR and may be involved in the development of DR.