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在克山病的防治及病因研究中,业已查明我国克山病病区人群的头发、血液及主要食粮中含硒量均低于非病区。这种低硒状态可能与食物中硒的摄入量较低有关。用硒制剂予防克山病的临床试验也收到了一定的效果。家畜白肌病的调查也初步揭示出在克山病病区内发生着因缺乏硒所致的一些动物缺硒病。Wright等人证明喂饲低硒饲料的绵羊,其血液在体外用Na_2Se~(75)O_3培养时,红血球对Se~(75)的摄取率增高,而且此摄取率反比于食物硒的摄入。此后,Burk等人将此法用于Kwashiorkor病的研究中,证明K氏病的儿童红血球Se~(75)。摄取的升高反映了他们体内硒含量的降低,暗示出利用体外红血球对Se~(75)的摄取可作为观察硒状态的一个指标。为了更为直接地证明克山病病区人群的低硒状态,我们建立了人血红血球与放射性Se~(75)的体外培养方法,观察了红血球对Se~(75)的摄取。本文报告此试验的初步结果。
In the prevention and treatment of Keshan disease and etiology, it has been found that the population of Keshan disease in our country hair, blood and the main dietary selenium content were lower than the non-ward. This low-selenium status may be related to the lower intake of selenium in foods. Clinical trials with selenium to prevent Keshan disease also received some results. Investigations of livestock white muscle disease have also revealed initially that some animals lacking selenium due to lack of selenium have selenium-deficiency disease in Keshan disease area. Wright et al. Demonstrated that when sheep fed low selenium diet, their blood uptake of Se ~ (75) increased with Na_2Se ~ (75) O_3 in vitro and the uptake was inversely proportional to the dietary selenium intake. Since then, Burk et al. Have used this method in the study of Kwashiorkor’s disease, proving Seh’s disease (75). The increase in uptake reflects a decrease in selenium levels in their bodies, suggesting that uptake of Se ~ (75) by in vitro red blood cells may be an indicator of Se status. In order to prove the low selenium status of population in Keshan disease district more directly, we established a method of culturing human erythrocytes and radioactive Se ~ (75) in vitro and observed the uptake of Se ~ (75) by erythrocytes. This article reports the preliminary results of this trial.