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以小剂量噻嗪类利尿剂为主的治疗方案能减少心血管事件的证据主要来自于氯噻酮,然而目前小剂量氢氯噻嗪(12.5～25.0mg)仍被广泛应用。该研究试图分析氢氯噻嗪和氯噻酮对收缩压和血钾变化的剂量反应关系。方法:在PubMed上检索1948-2008-07所有使用氢氯噻嗪或氯噻酮单药治疗的临
The evidence that small-dose thiazide-based diuretics-based regimens reduce cardiovascular events is mainly based on chlorthalidone, whereas the current low-dose hydrochlorothiazide (12.5-25.0 mg) is still widely used. This study sought to analyze the dose response of hydrochlorothiazide and chlorthalidone to changes in systolic blood pressure and potassium levels. METHODS: The PubMed was searched for all patients treated with hydrochlorothiazide or chlorthalidone monotherapy 1948-2008-07