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目的 探讨母婴联合免疫阻断乙型肝炎病毒宫内传播的效果。 方法 将 2 16例乙肝表面抗原阳性孕妇分组 ,母婴联合组 12 6例 ,孕妇自孕 2 8周起注射人乙型肝炎免疫球蛋白 (HBIG)2 0 0IU ,新生儿于 0、15d各注射HBIG 2 0 0IU ,然后于 1、2、7月龄各接种基因乙肝疫苗 (HBVac )2 0 μg。对照组 90例 ,只对新生儿进行免疫。母儿血清检测采用美国Abbott酶联免疫试剂测定 ,随访1年。 结果 联合免疫组婴儿宫内感染率低于对照 ( 19.5 1%与 35 .5 6 % ) ,慢性HBV感染率由13.33%降为 3.97% ,P均 <0 .0 5 ;联合免疫组及对照组新生儿出生时抗HBs检出率 ( 80 .95 %与 0 )及 1岁时保护性抗体产生率 ( 96 .0 3%与 86 .6 7% )均明显高于对照组 ,P均 <0 .0 5。 结论 孕妇及婴儿联合免疫可有效预防宫内感染且明显提高宫内感染阻断效果 ,减少慢性HBV感染率
Objective To explore the effect of combined immunization with mother and infant in blocking the intrauterine transmission of hepatitis B virus. Methods Two hundred and sixteen HBsAg positive pregnant women were divided into groups, and the mother-infant combination group was 126. The pregnant women were injected with HBIG201U from the 28th week of pregnancy, HBIG 200 IU, and then at the age of 1, 2, 7 months of vaccination gene hepatitis B vaccine (HBVac) 20 μg. The control group of 90 patients, only newborn immunization. Mother and child serum test using the United States Abbott enzyme-linked immunosorbent assay, followed up for 1 year. Results The intrauterine infection rate in the combined immunized group was lower than that in the control group (19.5 1% vs 35.56%), and the chronic HBV infection rate was reduced from 13.33% to 3.97% (P <0.05). The combined immunization and control groups The detection rate of anti-HBs (80.95% vs 0) and protective antibody (96.03% and 86.67%) at birth were significantly higher than those of control group .0 5. Conclusion Combined immunization of pregnant women and infants can effectively prevent intrauterine infection and significantly improve the intrauterine infection blocking effect and reduce the rate of chronic HBV infection