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本实验采用皮下注射法对Ｗｉｓｔａｒ大鼠进行了亚急性毒性研究，观察了环氧氯丙烷对大鼠糖代谢的影响。结果表明，环氧氯丙烷可引起大鼠糖代谢紊乱，导致血糖明显升高，肝糖原、肌糖原显著下降，血清巯基含量降低，与对照组相比均具有非常显著性差异，且存在明显的剂量－效应关系。病理组织学表明，染毒组大鼠肝、肾、脑等组织均有明显损伤，其损伤程度与剂量大小亦有关系。糖原染色可见，染毒组大鼠肝糖原颗粒明显减少。
Subcutaneous injection in this experiment Wistar rats were subacute toxicity study observed epichlorohydrin glucose metabolism in rats. The results showed that epichlorohydrin can cause disorder of glucose metabolism in rats, resulting in significantly increased blood glucose, glycogen, glycogen and hepatic glycogen significantly decreased serum thiol content, compared with the control group, there is a very significant difference, and there Significant dose-response relationship. Histopathological examination showed that the liver, kidney, brain and other tissues of the exposed group were significantly damaged, and the degree of damage was also related to the dose size. Glycogen staining shows that the exposure group rats hepatic glycogen granules was significantly reduced.