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目的:对50例弥漫大B细胞淋巴瘤(diffuse large B-cell lymphoma,DLBCL)的细胞遗传学及预后进行比较分析。方法:采用荧光原位杂交法(FISH)对所有DLBCL患者的石蜡组织进行p53、bcl-2、bcl-6及c-myc基因的检测,对其进行阳性率比较。以3例正常的扁桃体组织的石蜡切片作为阴性对照组。结果:经Cox模型似然比检验结果筛选,DLBCL患者的P53蛋白可作为独立的预后因素。p53蛋白检测为阳性者死亡风险高于p53蛋白检测为阴性者。结论:p53蛋白可作为DLBCL患者独立的预后因素,在疾病诊断初期即进行细胞遗传学检测可对DLBCL的预后进行准确分析。
Objective: To compare and analyze the cytogenetics and prognosis of 50 cases of diffuse large B-cell lymphoma (DLBCL). Methods: The expressions of p53, bcl-2, bcl-6 and c-myc in paraffin tissues of all DLBCL patients were detected by fluorescence in situ hybridization (FISH). Three cases of normal tonsil tissue paraffin section as a negative control group. Results: The Cox model likelihood ratio test results screening, DLBCL patients P53 protein can be used as an independent prognostic factor. Patients with a positive p53 protein have a higher risk of dying than those with a negative p53 protein. Conclusion: p53 protein can be used as an independent prognostic factor for patients with DLBCL. The prognosis of DLBCL can be accurately analyzed in the early stage of disease diagnosis, ie cytogenetics.