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目的观察静脉溶栓治疗对ＡＭＩ患者左室重构的影响。方法选择确诊为ＡＭＩ并经静脉溶栓治疗患者８２例，按临床非侵入性冠脉再通四项指标判定，８２例中再通４８例（再通组），未通３４例（未通组）。于梗塞后４～６周，平均５．４周行心脏彩色多普勒超声检查，测量左室舒张末期内径（ＬＶ）、左室射血分数（ＥＦ）、左室短轴缩短率（ＦＳ）、舒张早期峰值血流速度／舒张晚期峰值血流速度（Ｅ／Ａ）、血流经过二尖瓣口的降速率（ＤＣ）。结果溶栓再通组与未通组的ＬＶ、ＥＦ、ＦＳ、Ｅ／Ａ、ＤＣ分别相比有统计学差异。结论有效的静脉溶栓治疗能够抑制ＡＭＩ后的左室重构并改善左心室收缩和舒张功能。
Objective To observe the effect of intravenous thrombolytic therapy on left ventricular remodeling in patients with AMI. Methods Eighty-two patients diagnosed as AMI by intravenous thrombolysis were enrolled in this study. According to the four indexes of noninvasive coronary recanalization, 48 cases of recanalization (recanalization group), 34 cases failed of recanalization ). The left ventricular end-diastolic diameter (LV), left ventricular ejection fraction (EF), shortening of left ventricular fractional shortening (FS) were measured by color Doppler sonography at 5.4 weeks after the embolization. , Early diastolic peak flow velocity / late diastolic peak flow velocity (E / A), and decelerating rate (DC) of blood flow through the mitral valve. Results There was significant difference in LV, EF, FS, E / A and DC between thrombolytic group and failed group respectively. Conclusion Effective intravenous thrombolysis can inhibit left ventricular remodeling after AMI and improve left ventricular systolic and diastolic function.