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目的：观察血脉通对东莨菪碱、亚硝酸钠、乙醇致小鼠记忆障碍模型的影响。方法：采用东莨菪碱造成小鼠记忆获得障碍，用跳台法作行为检测；分别采用乙醇、亚硝酸钠造成小鼠记忆再现、记忆巩固障碍模型，用避暗法进行行为检测。结果：血脉通可减少东莨菪威模型跳台错误次数；对乙醇记忆再现障碍、亚硝酸钠记忆巩固障碍模型可延长进入暗室的潜伏期，减少其进入暗室的错误次数；血脉通大剂量还明显提高东莨菪碱模型的脑重指数。结论：血脉通对东莨菪碱、乙醇及亚硝酸钠引起的小鼠记忆障碍模型有不同程度的改善作用。
Objective: To observe the effect of Xuemaitong on memory impairment model induced by scopolamine, sodium nitrite and ethanol in mice. Methods: The scopolamine was used to cause memory impairment in mice. The behavior of the mice was detected by the method of step-down. Ethanol and sodium nitrite were used to model the memory reversal and memory consolidation obstacles respectively, and behavior detection was performed by avoidance of darkness. RESULTS: The blood circulation could reduce the number of errors in the platform jumping of the Dong Junwei model; the obstacles to the reconstruction of ethanol memory and the sodium nitrite memory consolidation model could prolong the incubation period into the dark room and reduce the number of errors in entering the dark room; the large dose of blood circulation also significantly increased scopolamine The model’s brain weight index. Conclusion: Xuemaitong has different degrees of improvement in mice with memory impairment caused by scopolamine, ethanol and sodium nitrite.