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糖尿病(Diabetes mellitus,DM)是独立于其他动脉硬化危险因素外引起心脏病及周围动脉疾病的主要原因,其所致的下肢血管病变是糖尿病的严重并发症之一,发病率是正常人的4倍。糖尿病不仅使大血管病变而致严重缺血性疾病,而且同时伴有侧支血管形成能力严重受损。一般来说,外周血管疾病患者其侧支形成足以代偿经阻塞动脉丧失的血流,但在糖尿病患者,因其侧支血管新生能力受损而使心肌、肢端、视网膜等严重缺血。因而,罹患下肢动脉硬化闭塞症的糖尿病患者是非糖尿病患者截肢率的五倍之多[1]。目前关于糖尿病患者新生血管形成缺陷的原因尚无定论。
Diabetes mellitus (DM) is the main cause of heart disease and peripheral arterial disease independent of other atherosclerosis risk factors. Its lower extremity vascular disease is one of the serious complications of diabetes, the incidence is normal 4 Times Diabetes mellitus not only causes serious ischemic diseases caused by macrovascular diseases, but also with severe impairment of collateral vessels. In general, peripheral vascular disease in patients with collateral formation sufficient to compensate for the loss of blood flow through the blocked artery, but in patients with diabetes, due to its collateral vessels impaired ability to impose myocardial, limb, retina and other severe ischemia. Thus, diabetic patients with lower extremity arteriosclerotic occlusive disease are five times more amputated than non-diabetic patients [1]. At present there is no conclusion about the reason of the defect of neovascularization in diabetic patients.