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目的 :探讨热休克蛋白 70 (HSP70 )在喉癌组织中的表达和临床意义。方法 :应用免疫组化 SP法 ,检测 46例喉癌组织中 HSP70的表达 ,并以 40例声带息肉组织为对照。结果 :HSP70在喉癌组织中的表达与在声带息肉中的表达差异有显著性意义 ;喉癌组织中 HSP70的表达与临床分型、分期及淋巴结转移无关 ,与喉癌病理分级和患者的预后有关。结论 :HSP70的表达可作为判断喉癌恶性程度和预后的重要指标。
Objective: To investigate the expression of heat shock protein 70 (HSP70) in laryngeal carcinoma and its clinical significance. Methods: Immunohistochemical SP method was used to detect the expression of HSP70 in 46 cases of laryngeal carcinoma, and 40 cases of vocal cord polyps were used as control. Results: The expression of HSP70 in laryngeal carcinoma was significantly different from that in vocal cord polyp. The expression of HSP70 in laryngeal carcinoma was not associated with clinical classification, stage and lymph node metastasis, but also with the pathological grade of laryngeal carcinoma and the prognosis of patients related. Conclusion: The expression of HSP70 can be used as an important index to judge the malignant degree and prognosis of laryngeal cancer.