论文部分内容阅读
为了证实血清肌酸激酶(CK)和肌红蛋白(Mb)对各种神经肌病的诊断价值,作者对111例患者(肌营养不良71例,肌强直病6例,重症肌无力7例,神经原性肌萎缩27例,10例X 连锁杜兴氏肌营养不良(DMD)肯定携带者(definite carrier)及86例女性可能携带者(possible carrier)进行了研究,同时设36例(女22例,男16例)健康者作对照组.结果发现:对照组中,男性平均正常上限值为CK66U/L,Mb91μg/L;女性CK 为62U/L 和Mb90μg/L。CK 或Mb 与年龄之间及CK 和Mb 二者之间均未发现明显的相关性。病人组中,DMD 的CK 活性(730～11555U/L 和Mb 含量(140～1400μg/L)特别高,同时发现CK 和Mb 与年龄呈明显负相关,而CK 与Mb 之间正相关(P<0.01)。肌强直、肌萎缩性侧索硬化症(ALS)及脊肌性肌萎缩(SMA)平均CK 活性和Mb 浓
To confirm the diagnostic value of serum creatine kinase (CK) and myoglobin (Mb) for various neuromuscular diseases, the authors evaluated 111 patients (71 with muscular dystrophy, 6 with myotonic disease, 7 with myasthenia gravis, 27 cases of neurogenic muscle atrophy, 10 cases of definite carriers of X-linked Duchenne muscular dystrophy (DMD) and 86 cases of possible carriers were studied. At the same time, 36 cases (female 22 (16 males and 16 females) as control group.The results showed that in the control group, the average upper limit of normal men was CK66U / L, Mb91μg / L, female CK was 62U / L and Mb90μg / L.CK or Mb and age And between CK and Mb were not significantly correlated.The CK activity (730 ~ 11555U / L and Mb ~ 140 ~ 1400μg / L) of DMD patients were particularly high in patients, and CK and Mb (P <0.01), and the mean CK activity and Mb concentration of myotonic, amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA)