前列腺增生雌激素受体与血管内皮细胞生长因子表达的研究

• 作 者: 王继忠 毛普德 曾德朗 王建军 邓显忠 谢贤镛 朱治建 周继雍
• 机 构: 川北医学院附属医院!四川南充637007,川北医学院附属医院!四川南充637007,川北医学院附属医院!四川南充637007,川北医学院附属医院!四川南充637007,川北医学院附属医院!四川南充63
• 出 处: 川北医学院学报
• 发表日期: 2000年01期
• 关键词: 前列腺增生 雌激素受体 血管内皮生长因子 雌激素效应

为了探讨雌激素致BPH的机理。用单克隆免疫组化方法测定前列腺增生石蜡切片 30例、膀胱颈纤维化 8例中ER和VEGF。BPH组ER阳性率 86 6 7% (2 6 / 30 )、VEGF阳性率 40 % (12 / 30 ) ,对照组ER 6 2 5 % (5 / 8)、VEGF 2 5 % (2 / 8) ,其中纤维肌腺瘤型ER 87%、VEGF 5 3%。纤维肌腺瘤 ,纤维肌型的ER均显著高于对照组 ,纤维肌腺瘤的腺上皮细胞浆VEGF显著高于对照组。雌激素致BPH是通过ER所引起雌激素效应 ,加上VEGF增加 ,提供营养 ,进一步促进前列腺增生。

To explore the mechanism of estrogen-induced BPH. Monoclonal immunohistochemistry was used to detect the expression of ER and VEGF in 30 cases of benign prostatic hyperplasia and 8 cases of bladder neck fibrosis. The positive rate of ER was 95% (5/8), VEGF 2 5% (2/8), the positive rate of VEGF in BPH group was 86.67% (26/30) Among them, fibroadenoma ER 87% and VEGF 5 3%. Fibroadenoma, fibroids type ER were significantly higher than the control group, fibroadenoma glandular epithelial cell plasma VEGF was significantly higher than the control group. Estrogen-induced BPH is caused by ER-induced estrogen effect, coupled with increased VEGF to provide nutrition and further promote prostate hyperplasia.