论文部分内容阅读
目的:探讨乳腺黏液癌的超声图像及组织病理学特征,以提高乳腺黏液癌的早期诊断率。方法:选择32例经手术、病理确诊为乳腺黏液癌的患者,分析其超声图像及组织病理学特征。结果:病理检查确诊单纯型黏液癌21例,混合型黏液癌11例;以超声检查提示乳腺癌为正确诊断,超声的诊断敏感度为56.25%;单纯型和混合型的诊断敏感度分别为47.62%和72.73%,两者比较,差异无统计学意义(χ2=0.496,P>0.05)。混合型黏液癌边界不清、形态不规则、内部回声不均匀、包块后方声衰减、沙砾样钙化均高于单纯型黏液癌(P<0.05)。其他图像特征两组间无明显差异(P>0.05)。混合型雌激素受体(ER)、孕激素受体(PR)、Ki67阳性率高于单纯型(P<0.05)。两组人类表皮生长因子受体2(HER-2)、人体抑癌基因(P53)阳性率比较,差异无统计学意义(P>0.05)。结论:乳腺黏液癌尤其是单纯型乳腺黏液癌不具备乳腺癌的典型影像特征;应用超声诊断时应重视病变的少见征象及临床特点,以提高诊断的准确性。
Objective: To investigate the ultrasonic image and histopathological features of mucinous carcinoma of breast in order to improve the early diagnosis rate of mucinous carcinoma of the breast. Methods: Thirty-two patients with pathologically diagnosed breast mucinous carcinoma were selected for analysis of their ultrasound images and histopathological features. Results: Twenty-one cases of simple mucinous carcinoma and 11 cases of mixed mucinous carcinoma were diagnosed by pathological examination. The diagnostic sensitivity of ultrasound was 56.25% by ultrasound examination. The diagnostic sensitivities of simple and mixed type were 47.62 % And 72.73% respectively. There was no significant difference between them (χ2 = 0.496, P> 0.05). Mixed mucinous carcinoma of the border is unclear, irregular shape, internal echo is not uniform, decay of the mass after the decay, gritty calcification were more than simple mucinous carcinoma (P <0.05). Other image features no significant difference between the two groups (P> 0.05). Mixed estrogen receptor (ER), progesterone receptor (PR), Ki67 positive rate was higher than the simple type (P <0.05). There were no significant differences in the positive rates of HER-2 and P53 between the two groups (P> 0.05). CONCLUSIONS: Breast mucinous carcinoma, especially simple breast mucinous carcinoma, does not have the typical features of breast cancer. Ultrasound diagnosis should pay attention to the rare signs and clinical features of lesions to improve the diagnostic accuracy.