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目的探讨奥曲肽治疗肝硬化合并上消化道大出血的临床疗效。方法将52例肝硬化合并食管胃底静脉曲张破裂大出血的住院患者随机分为奥曲肽治疗组26例和垂体后叶素对照组26例,观察两组显效时间、平均止血时间、24 h止血率、再出血率等。结果治疗组的平均显效时间及平均止血时间、再出血率均低于对照组,24 h止血率高于对照组,两组比较差异均有统计学意义(P<0.05)。结论奥曲肽治疗肝硬化合并食管胃底静脉曲张破裂大出血的止血效果明显优于垂体后叶素对照组,加之配合合理、及时有效的抢救措施,明显提高了临床疗效,改善了患者的生活质量。
Objective To investigate the clinical efficacy of octreotide in treating cirrhosis with upper gastrointestinal hemorrhage. Methods Totally 52 inpatients with cirrhosis and esophagogastric variceal bleeding were randomly divided into octreotide treatment group (n = 26) and pituitrin control group (n = 26). The effective time, mean hemostasis time, hemostasis rate at 24 h, Rebleeding rate. Results The mean effective time, mean hemostasis time and rebleeding rate in the treatment group were all lower than those in the control group, and the bleeding rate at 24 h was higher than that in the control group. There was significant difference between the two groups (P <0.05). Conclusion The octreotide treatment of cirrhosis complicated with esophageal variceal bleeding hemostasis effect was significantly better than pituitrin control group, combined with reasonable and timely and effective rescue measures, significantly improve the clinical efficacy and improve the quality of life of patients.