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目的:探讨PTEN蛋白在前列腺癌组织中的表达及其临床意义。方法:应用免疫组织化学S-P方法,检测前列腺癌及良性前列腺增生组织中PTEN蛋白的表达。结果:PTEN蛋白表达阳性随肿瘤细胞病理分级、临床分期的增高,PTEN蛋白阳性表达率降低。结论:PTEN蛋白异常表达在前列腺癌的进展中有重要作用,检测PTEN蛋白的表达有助于判断病情及预后。
Objective: To investigate the expression of PTEN protein in prostate cancer and its clinical significance. Methods: Immunohistochemical S-P method was used to detect the expression of PTEN protein in prostate cancer and benign prostatic hyperplasia tissues. Results: The positive expression of PTEN protein was correlated with the pathological grade of tumor cells and the clinical stage. The positive rate of PTEN protein was decreased. Conclusion: The abnormal expression of PTEN protein plays an important role in the progression of prostate cancer. Detecting the expression of PTEN protein is helpful to judge the condition and prognosis.