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[目的]通过观察环氧化酶2(Cyclooxygenase-2,COX-2)在大肠腺瘤、大肠癌中的表达及其与大肠癌生物学特性的关系,初步探讨其在大肠癌发生、发展过程中的作用机制。[方法]应用免疫组织化学染色法对78例大肠癌组织、21例大肠腺瘤组织和13例正常大肠黏膜组织进行免疫组化染色;应用χ2检验分析COX-2的表达情况及其与大肠癌临床病理特征的关系。[结果]大肠癌组织中COX-2阳性表达率为78.21%,明显高于大肠腺瘤的52.38%和正常大肠黏膜组织的7.69%(P<0.05);COX-2表达与大肠癌的Duke’s分期、分化程度、淋巴结转移有相关性(P<0.05),而与大肠癌患者的性别、组织学类型无关(P>0.05)。[结论]COX-2在大肠癌组织中表达率明显高于大肠腺瘤,而正常大肠黏膜中表达率极低或不表达;COX-2表达与大肠癌生物学特性有明显相关性。
[Objective] To investigate the expression of Cyclooxygenase-2 (COX-2) in colorectal adenoma and colorectal carcinoma and its relationship with the biological characteristics of colorectal cancer, and to explore its role in the occurrence and development of colorectal cancer In the mechanism of action. [Methods] Immunohistochemical staining was used to detect the expression of COX-2 in 78 cases of colorectal carcinoma, 21 cases of colorectal adenoma and 13 cases of normal colorectal mucosa. The expression of COX-2 and its correlation with colorectal cancer Clinicopathological characteristics of the relationship. [Results] The positive expression rate of COX-2 in colorectal cancer was 78.21%, which was significantly higher than that in colorectal adenoma (52.38%) and normal colorectal mucosa (7.69%, P <0.05). The expression of COX-2 was correlated with Duke’s stage , Differentiation degree and lymph node metastasis (P <0.05), but not with gender and histological types of patients with colorectal cancer (P> 0.05). [Conclusion] The expression of COX-2 in colorectal carcinoma was significantly higher than that in colorectal adenomas, while the expression of COX-2 in colorectal mucosa was very low or not. The expression of COX-2 was significantly correlated with the biological characteristics of colorectal carcinoma.