A comprehensive cardiotoxicity assay by combining high-throughput multiple ion channel screening wit

• 作 者: He-mingWEI Jian-junWU YingYing
• 机 构: NationalHeartResearchInstituteSingaporeNationalHeartCentreSingapore,Cardiovascular&,MetabolicDiso
• 出 处: 中国药理学与毒理学杂志
• 发表日期: 2015年S1期
• 关键词: CARDIOTOXICITY ion channels action POTENTIALS card cardiotoxicity ion channels a
• 基金项目: The project supported by National Medical Research Council(NMRC CG12Aug09&NMRC EDG10may050)； National Research Foundation(NRF2008-CRP003-02)of Singapore and Ministry of Science,Technology and Inno

OBJECTIVE Cardiotoxicity refers to drug-induced arrhythmia such as Torsades de pointes.Current single ion channel(hERG)-based assay generates-30% false results.The aim is to establish an advanced in vitro cardiotoxicity assay by incorporating high through