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目的 研究苯系毒物作用下人体内抗EB病毒抗体水平的变化。方法 选择苯系毒物接触工人 5 5 8人和无接触者 372人作为对照 ,用ELISA方法检测EB病毒抗体。结果 (1)苯系毒物接触者体内EB病毒IgA/VCA抗体阳性检出率 (2 6 .0 % )与非接触者阳性检出率 (11.3% )差异有显著性(P <0 .0 1) ;(2 )苯与甲苯、二甲苯均能引起体内IgA/VCA上升 ,其抗体滴度≥ 1∶10 0的阳性检出率三者差异均无显著性 (P >0 .0 5 ) ;(3) 0 .2～ 0 .5年的苯系毒物接触工龄即可使体内的IgA/VCA明显上升 ,但其抗体水平并不随着接触工龄的增加而呈上升趋势。结论 职业性接触苯系毒物可能使潜伏于人体内的EB病毒受到激活。
Objective To study the changes of anti-Epstein-Barr virus (EBV) antibody in human under the action of benzene poison. Methods A total of 558 benzene-exposed workers and 372 non-contact workers were selected as controls to detect Epstein-Barr virus antibodies by ELISA. Results (1) The positive detection rate of Epstein-Barr virus IgA / VCA antibody (26.0%) and non-contact positive rate (11.3%) of benzene poison contact patients were significantly different (P <0.01 ); (2) Both benzene and toluene and xylene could cause the increase of IgA / VCA in vivo. The positive rate of antibody titer ≥ 1:10 was not significant (P> 0.05); (3) 0.2-2.5 years of exposure to benzene-based toxicants can make the body’s IgA / VCA significantly increased, but the antibody level does not increase with the increase of working age. Conclusions Occupational exposure to benzene-based poisons may activate Epstein-Barr virus that is latent in the human body.