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肿瘤转移是一个多阶段、多途径、涉及多基因及其信号通路变化的一系列复杂过程。了解肿瘤转移相关基因的信号传导通路以及对肿瘤转移的作用机制,为寻找抑制肿瘤转移的关键靶点具有重要的意义。Ezrin高表达与肿瘤转移密切相关,它可通过改变肿瘤细胞极性及细胞运动、调节肿瘤细胞间黏附及细胞与细胞外基质黏附、参与肿瘤细胞内信号转导而影响恶性肿瘤转移。Ezrin过度表达可以破坏正常细胞内信号传递网络的平衡,其中主要涉及的为细胞信号转导相关分子(Rho)及受体酪氨酸蛋白激酶等信号传导途径。Ezrin借助于细胞内错综复杂的信号转导网络调控细胞的形态构成、黏附、吞噬、运动、血管形成等一系列的生物学过程,最终实现肿瘤细胞的侵袭和转移。本文就Ezrin蛋白的信号转导通路及其对肿瘤转移作用的研究进展做一综述。
Tumor metastasis is a multi-stage, multi-path involved in a series of complex processes involving multiple genes and their signaling pathways. To understand the signal transduction pathways of tumor metastasis-related genes and the mechanism of action on tumor metastasis is of great significance for finding a key target of inhibiting tumor metastasis. Ezrin expression is closely related to tumor metastasis. It can affect the metastasis of malignant tumor by changing the cell polarity and cell motility, regulating the adhesion between tumor cells and the adhesion of cells and extracellular matrix, and participating in signal transduction in tumor cells. Ezrin overexpression can disrupt the balance of normal intracellular signal transduction networks, which are mainly involved in signal transduction pathways such as cell signal transduction related molecules (Rho) and receptor tyrosine protein kinases. Ezrin regulates the formation, adhesion, phagocytosis, movement, angiogenesis and a series of biological processes by means of intricate signal transduction network in the cell, finally realizing the invasion and metastasis of tumor cells. This review summarizes the signal transduction pathway of Ezrin and its research progress on tumor metastasis.