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目的 :研究 3种鼠 (小白鼠A、草原兔尾鼠B、子午沙鼠C)对戊肝病毒 (HEV)的反应。方法 :检查疫区捕获的小林姬鼠 ;对人工饲养繁殖后的B、C鼠实验感染HEV :第 1次用已证实含HEV·RNA的人粪便悬液攻击A、B、C 3种鼠 ;第 2次用已感染HEV的小林姬鼠和B鼠肝组织攻击 ,观察各种反应。结果 :第 1次攻击后临床表现少而轻 ,仅 2 0 %B鼠出现精神萎靡 ,A、B、C鼠全部有酶血症 ,C鼠排毒HCV·RNA+占 2 5 % ,肝组织普遍有病理反应 (占 30 %～ 10 0 % )。感染后死亡仅见B鼠 (占 5 0 % )。结论 :实验用 3种鼠均可感染HEV ,应重视其在传播中的作用 ,并可从中筛选动物模型目的 :研究 3种鼠 (小白鼠A、草原兔尾鼠B、子午沙鼠C)对戊肝病毒 (HEV)的反应。方法 :检查疫区捕获的小林姬鼠 ;对人工饲养繁殖后的B、C鼠实验感染HEV :第 1次用已证实含HEV·RNA的人粪便悬液攻击A、B、C 3种鼠 ;第 2次用已感染HEV的小林姬鼠和B鼠肝组织攻击 ,观察各种反应。结果 :第 1次攻击后临床表现少而轻 ,仅 2 0 %B鼠出现精神萎靡 ,A、B、C鼠全部有酶血症 ,C鼠排毒HCV·RNA+占 2 5 % ,肝组织普遍有病理反应 (占 30 %～ 10 0 % )。感染后死亡仅见B鼠 (占 5 0 % )。结论 :实验用 3种鼠均可感染HEV ,应重视其在传播中的作用 ,并可从中筛选动物模型
OBJECTIVE: To investigate the response of three kinds of mice (mouse A, prairie B, and gerbil C) to hepatitis E virus (HEV). Methods: The Apodemus agrarius, which was caught in the epidemic area, was infected. The infected rabbits B and C after artificial feeding and breeding were infected with HEV. The first three kinds of mice were challenged with A, B, The second time infected with HEV infected mice and B rat liver tissue attack, observe a variety of reactions. Results: After the first attack, the clinical manifestations were less and less severe, only 20% of B rats showed apathetic symptoms, all of A, B and C mice had dementia, C and C detoxified HCV RNA 25% and hepatic tissues generally Pathological response (30% ~ 100%). Only B rats were found dead after infection (50%). CONCLUSION: HEV can be infected in all three kinds of rats in experiment, and its role in transmission should be emphasized and animal models should be screened out. OBJECTIVE: To study the effects of three kinds of mice (mouse A, prairie B, and gerbil C + M) Hepatitis E virus (HEV) response. Methods: The Apodemus agrarius, which was caught in the epidemic area, was infected. The infected rabbits B and C after artificial feeding and breeding were infected with HEV. The first three kinds of mice were challenged with A, B, The second time infected with HEV infected mice and B rat liver tissue attack, observe a variety of reactions. Results: After the first attack, the clinical manifestations were less and less severe, only 20% of B rats showed apathetic symptoms, all of A, B and C mice had dementia, C and C detoxified HCV RNA 25% and hepatic tissues generally Pathological response (30% ~ 100%). Only B rats were found dead after infection (50%). CONCLUSION: All three kinds of mice can be infected with HEV in experiment, their role in transmission should be emphasized and animal models should be selected