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材料和方法益康唑(Econazole)是一种新的广谱抗真菌药。化学名为1-[2-(2,4-二氯苯基)-2-(4-氯苄氧基)-乙基]咪唑硝酸盐。它对皮肤真菌、酵母菌(如白色念珠菌)、双相型真菌、放线菌属和革兰氏阳性细菌有效。其抗真菌机制是改变细胞壁的通透性,药物透入细胞后抑制核糖核酸和蛋白质合成,在细胞质内形成溶解区,进而类脂代谢被抑制,最后导致细胞质内的膜系统分解,使含类脂代谢的终末产物沉着在线粒体内。
Materials and Methods Econazole is a new broad-spectrum antifungal drug. Chemical name is 1- [2- (2,4-dichlorophenyl) -2- (4-chlorobenzyloxy) -ethyl] imidazole nitrate. It is effective against dermatophytes, yeasts (such as Candida albicans), biphasic fungi, actinomycetes, and Gram-positive bacteria. The antifungal mechanism is to change the permeability of the cell wall, the drug penetrates into the cell and inhibits the synthesis of ribonucleic acid and protein, forming a lytic region in the cytoplasm, which in turn inhibits lipid metabolism and finally leads to the breakdown of the membrane system in the cytoplasm, Lipid-metabolizing end products are sedated in the mitochondria.