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目的探讨亚低温治疗对重型颅脑损伤患者血清中肿瘤坏死因子-α(TNF-α)、白细胞介素(IL)-1β、IL-6、IL-8的影响及临床意义。方法选择符合条件的重型颅脑损伤患者〔格拉斯哥昏迷评分(GCS)3~8分〕共23例,于伤后24h内行亚低温治疗,控制直肠温度33~35℃,持续5d;对照组20例(GCS3~8分)。采用酶联免疫吸附法(ELISA)监测两组患者外周血清TNF-α、IL-1β、IL-6、IL-8在伤后第1,2,3,4天的动态变化。结果亚低温治疗组患者血清TNF-α、IL-1β、IL-6、IL-8浓度较常规治疗组明显降低(P<0.05)。结论亚低温通过降低重型颅脑损伤患者血清中细胞因子的水平,减少了患者多器官功能障碍综合征的发生。
Objective To investigate the effects of mild hypothermia on the levels of tumor necrosis factor-α (TNF-α), interleukin (IL) -1β, IL-6 and IL-8 in patients with severe craniocerebral injury and its clinical significance. Methods A total of 23 patients with severe craniocerebral injury who met the criteria of severe craniocerebral injury (Glasgow coma score of 3 to 8) were treated with mild hypothermia 24 hours after injury and the rectal temperature was controlled at 33-35 ° C for 5 days. The control group of 20 patients (GCS 3-8 points). The dynamic changes of TNF-α, IL-1β, IL-6 and IL-8 in the serum of the two groups were detected by enzyme-linked immunosorbent assay (ELISA) Results The serum levels of TNF-α, IL-1β, IL-6 and IL-8 in the mild hypothermia group were significantly lower than those in the conventional treatment group (P <0.05). Conclusion Mild hypothermia can reduce the incidence of multiple organ dysfunction syndrome in patients with severe craniocerebral injury by reducing the levels of cytokines.