论文部分内容阅读
目的分析局部晚期非小细胞肺癌预后的相关影响因素。方法选取威海市中心医院2011—2012年收治的局部晚期非小细胞肺癌患者89例,患者均随访3年,将3年内生存患者作为生存组,死亡患者作为死亡组,回顾性分析其临床治疗,统计两组患者的性别、年龄、KPS评分、体质量减轻情况、病灶大小及数目、治疗方式、细胞分化情况等,分析影响患者预后的因素。结果经过随访可知,89例患者中,3年内生存17例,生存率为19.1%,死亡72例,病死率为80.9%。经单因素分析结果可知,生存组KPS<60分、体质量减轻≥5%、临床ⅢB期、多发病灶、采用手术治疗、同步放化疗占比低于死亡组,差异有统计学意义(P<0.05)。经多因素分析可知,KPS<60分、临床ⅢB期为独立影响因素,差异有统计学意义(P<0.05)。结论影响局部晚期非小细胞肺癌患者预后的相关因素比较多,临床治疗时应重点注意这些因素,尤其是独立影响因素,以提高患者的远期生存率,改善患者预后。
Objective To analyze the related factors of the prognosis of locally advanced non-small cell lung cancer. Methods 89 patients with locally advanced non-small cell lung cancer admitted to Weihai Central Hospital from 2011 to 2012 were selected. All patients were followed up for 3 years. Survival patients within 3 years as the survival group and death patients as the death group were retrospectively analyzed for clinical treatment, Statistics of two groups of patients gender, age, KPS score, weight loss, the size and number of lesions, treatment, cell differentiation, analysis of prognostic factors in patients. Results After follow-up, among the 89 patients, 17 patients survived within 3 years, the survival rate was 19.1%, and 72 patients died. The fatality rate was 80.9%. The results of univariate analysis showed that the survival group KPS <60, weight loss ≥ 5%, clinical stage Ⅲ B, multiple lesions, the use of surgery, concurrent radiotherapy and chemotherapy accounted for less than the death group, the difference was statistically significant (P < 0.05). By multivariate analysis, KPS <60 points, clinical stage Ⅲ B independent factors, the difference was statistically significant (P <0.05). Conclusion There are many related factors affecting the prognosis of patients with locally advanced non-small cell lung cancer. These factors should be paid special attention to in clinical treatment, especially independent factors to improve the long-term survival rate of patients and improve the prognosis of patients.