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肝硬化患者的高γ球蛋白血症主要是IgA增高所致。这在酒精性肝病(ALD)尤为突出。肝病中IgA升高的机理不一,本文就各种有关假说综述如下。IgA的结构与生物学 IgA是外分泌液中的主要抗体,其合成率高于其他免疫球蛋白。它对粘膜表面有重要保护作用。 IgA单体(mIgA)有三种,即IgA、IgA2m(1)和IgA 2m(2)。外分泌液含IgA多聚体(pIgA;即IgA二聚体和四聚体),和与之相联的两种多肽——J链和分泌成分(SC)。J链由浆细胞产生;SC是一种跨膜蛋白,即上皮细胞的多聚Ig受体(polu-Ig-R)的水解产物。SC以游离糖蛋白形式存在于某些外分泌液,血清
Patients with cirrhosis of high gamma globulin is mainly due to increased IgA. This is especially true in alcoholic liver disease (ALD). The mechanism of IgA increase in liver disease is different, this article reviews the various hypotheses below. The structure and biology of IgA IgA is the major antibody in exocrine fluid and has a higher rate of synthesis than other immunoglobulins. It has an important protective effect on the mucosal surface. IgA, IgA2m (1) and IgA 2m (2) are three types of IgA monomers (mIgA). Exocrine fluids contain IgA multimers (pIgA; ie, IgA dimers and tetramers), and two polypeptides associated therewith, the J chain and the secreted fraction (SC). The J chain is produced by plasma cells; SC is a transmembrane protein, the hydrolysates of polu-Ig-R in epithelial cells. SC exists as free glycoprotein in some exocrine fluid, serum