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本文旨在评定 C 肽的胰高血糖素刺激应答是否能预测尿病(DM)的正确治疗。患者268例,除 DM 外无其他疾病。其中215例用饮食控制和胰岛素治疗,53例用饮食控制或合用口服降糖药(磺酰脲类)治疗。患者禁食1夜后,在门诊于静注1 mg 胰高血糖素前和后6 min 分别测定血清 C 肽(CPR)浓度。此后,胰岛素治疗组按刺激后 C 肽值高低排队依次入院。入院后,停用胰岛素而单用饮食控制治疗。当空腹血糖<144mg/dl至少连续2天,且24小时无糖尿时,患者被认为不用胰岛素而代谢控制满意,因此为非胰岛素依赖型糖尿病(NIDDM)。如果单用饮食控制4天后,患者不符合上述标准,再加用磺酰脲(1 g 每日3次)治疗4天。如果代谢仍未被满意控制,用胰岛素治疗。连续10例
This article aims to assess whether the glucagon stimulation response of C-peptide predicts the correct treatment of diabetes mellitus (DM). 268 patients, no other diseases except DM. Among them, 215 cases were treated with diet control and insulin, and 53 cases were treated with diet control or oral hypoglycemic agents (sulfonylureas). One night after the patient was fasted, serum C-peptide (CPR) concentrations were measured before and 6 minutes after intravenous injection of 1 mg of glucagon in the clinic. Since then, the insulin treatment group according to the level of C-peptide after queuing were admitted to hospital. After admission, disable insulin and control diet alone. When fasting plasma glucose <144 mg / dl for at least 2 consecutive days and no glycosuria at 24 hours, the patient is considered not metabolically controlled with insulin and is therefore non-insulin dependent diabetes mellitus (NIDDM). If the patient does not meet the above criteria after 4 days of diet control alone, add sulfonylurea (1 g 3 times a day) for 4 days. If the metabolism has not been satisfactorily controlled, use insulin. 10 consecutive cases