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肾素-血管紧张素系统(RAS)主要存在于循环系统中,胃肠道同样也有RAS成分的表达,且分布广泛。胃肠道的不同部位所含的RAS成分不同,这些成分主要涉及水电解质平衡、炎性反应、细胞增殖、纤维化、平滑肌功能调控等方面。本文重点介绍RAS在胃肠道的表达及其在胃肠道疾病中的病理生理机制,并对RAS在胃肠道疾病如消化性溃疡、胃肠道肿瘤、肠系膜缺血和炎症性肠病的防治方面的研究进展进行了综述。
The renin-angiotensin system (RAS) is mainly found in the circulatory system. The gastrointestinal tract also expresses RAS components and is widely distributed. Different parts of the gastrointestinal tract contain different components of RAS, these components are mainly involved in water and electrolyte balance, inflammatory response, cell proliferation, fibrosis, smooth muscle function and so on. This article focuses on the expression of RAS in the gastrointestinal tract and its pathophysiological mechanisms in gastrointestinal diseases, and RAS in gastrointestinal diseases such as peptic ulcer, gastrointestinal cancer, mesenteric ischemia and inflammatory bowel disease The research progress of prevention and cure are summarized.