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一种恶性肿瘤经化疗完全缓解后长期继续化疗中又发生第二种恶性疾病的情况,已有报道。多发性骨髓瘤和何杰金氏病又可发生急性粒细胞性白血病,后者可能是第一种恶性疾病的自然病史的一部分,也可能是长期化疗的合并症。本文报告一例多发性骨髓瘤在环磷酰胺治疗缓解期间回盲部又发生组织细胞性淋巴瘤,此例似表示,二者非为同一疾病,与化疗有关。患者为45岁男性白人,因在一次运动中右第六肋骨骨折入院,经临床、X线、实验室、骨髓穿刺及免疫学等全面检查,确诊为多发性骨髓瘤。随后开始环磷酰胺治疗,首次1200 mg iv,其后600 mg iv/日,一周内总量3 gm。尔后用环磷酸胺100mg/日,强地
It has been reported that a second malignant disease occurs again and again after long-term chemotherapy after complete remission of malignant tumors. Multiple myeloma and Hodgkin’s disease can occur with acute myeloid leukemia, which may be part of the natural history of the first malignant disease and may also be a complication of long-term chemotherapy. This article reports a case of multiple myeloma in the treatment of cyclophosphamide remission occurred in the ileocecal tissue histiocytosis, this is an example that the two are not the same disease, and chemotherapy. The 45-year-old male was admitted to hospital because of a right sixth-rib fracture in a single exercise and was diagnosed with multiple myeloma by comprehensive examination of clinical, X-ray, laboratory, bone marrow puncture and immunology. Cyclophosphamide is then started, 1200 mg iv for the first time, followed by 600 mg iv / day for a total of 3 gm in one week. After cyclophosphamide 100mg / day, strong