论文部分内容阅读
目的探讨多西他赛联合FP方案微泵节拍化疗治疗不能手术的晚期胃癌患者的临床疗效和不良反应。方法选择36例不能手术治疗的晚期胃癌患者,以5-氟尿嘧啶0.375g/d持续静脉输注21d,顺铂10mg/d持续输注5d,休息2d,每周重复,共2次;国产多西他赛20mg持续静脉输注1h,第1、4、8、11、15、18d给药,用药3周后休息1周,28d为1个周期,每治疗2个周期后评价疗效。结果 36例患者总有效率(RR)为55.6%(20/36),疾病控制率(DCR)为97.2%(35/36),1年生存率为88.9%(32/36),18个月生存率为61.1%(22/36),2年生存率为13.9%(5/36),生活质量明显改善,Ⅲ度不良反应少见,无Ⅳ度不良反应。结论多西他赛联合FP方案微泵节拍化疗治疗晚期胃癌具有一定疗效,毒副反应小,依从性高,可作为晚期胃癌的一种有效治疗手段。
Objective To investigate the clinical efficacy and adverse reactions of docetaxel combined with FP protocol micropump chemosensitivity in the treatment of patients with advanced gastric cancer who are inoperable. Methods Thirty-six patients with advanced gastric cancer who were not surgically treated were treated with intravenous infusion of 5-Fluorouracil 0.375g / d for 21 days and cisplatin 10mg / d for 5 days. The patients were rested for 2 days and resumed weekly for 2 times. He race 20mg continuous intravenous infusion 1h, the first 1,4,8,11,15,18 d administration, 3 weeks after treatment, rest for 1 week, 28d for a cycle of evaluation after 2 cycles of treatment efficacy. Results The total effective rate (RR) of 36 patients was 55.6% (20/36), the disease control rate (DCR) was 97.2% (35/36), the 1-year survival rate was 88.9% (32/36) The survival rate was 61.1% (22/36). The 2-year survival rate was 13.9% (5/36). The quality of life was significantly improved. The grade 3 adverse reactions were rare, and there was no grade 4 adverse reaction. Conclusion Docetaxel combined FP micro-pump chemoembolization in the treatment of advanced gastric cancer has a certain effect, small side effects, high compliance, can be used as an effective treatment of advanced gastric cancer.