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［目的］探讨大肠癌组织中雌激素受体（ＥＲ）表达与大肠癌生物学行为的关系。［方法］采用免疫组织化学法检测９４例大肠癌组织中ＥＲ表达。［结果］ＥＲ的阳性表达与患者性别、年龄、肿瘤发生部位无明显相关性（Ｐ＞０．０５）；Ｄｕｋｅｓ’Ａ、Ｄ组的ＥＲ阳性率显著高于Ｄｕｋｅｓ’Ｃ、Ｄ期（Ｐ＜０．０１）；肿瘤生长于浆膜层内者ＥＲ阳性率显著高于肿瘤已浸润至浆膜层外者（Ｐ＜０．０５）；高分化腺癌ＥＲ阳性率显著高于低分化腺癌者（ｐ＜０．０５）。［结论］研究雌激素受体对探讨大肠癌的发病机制有一定的帮助，可作为判断预后的参考，对大肠癌病人行内分泌治疗具有指导意义。
[Objective] To explore the relationship between estrogen receptor (ER) expression and biological behavior of colorectal cancer in colorectal cancer. [Methods] Immunohistochemistry was used to detect the expression of ER in 94 cases of colorectal cancer. [Results] There was no significant correlation between the positive expression of ER and the patient’s sex, age and tumor site (P>0.05). The positive rate of ER in Dukes’A and D group was significantly higher than that of Dukes’C and D period (P< 0.01); The ER positive rate of tumors growing in the serosa layer was significantly higher than that of tumors that had infiltrated into the serosa (P<0.05); the positive rate of ER in well-differentiated adenocarcinoma was significantly higher than that of poorly differentiated adenocarcinoma (p<0.05). [Conclusion] The study of estrogen receptor is helpful to explore the pathogenesis of colorectal cancer, and it can be used as a reference for judging the prognosis. It has guiding significance for the endocrine therapy of colorectal cancer patients.