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目的分析大剂量甲氨蝶呤治疗骨肉瘤的临床情况。方法骨肉瘤患者30例均行大剂量甲氨蝶呤治疗,分析患者临床治疗具体情况。结果 30例骨肉瘤患者近期疗效总有效率为73.3%(22/30),不良反应主要包括消化道不适、骨髓抑制、肝功能损害、皮肤黏膜损伤。结论大剂量甲氨蝶呤治疗骨肉瘤具有良好效果,但大剂量甲氨蝶呤有较强化疗药物毒性,不良反应高,需密切监测患者血药浓度,积极处理各种并发症,保证患者可以顺利化疗。
Objective To analyze the clinical situation of high dose methotrexate in the treatment of osteosarcoma. Methods Thirty patients with osteosarcoma were treated with high-dose methotrexate, the clinical treatment of patients with specific conditions. Results The total effective rate of the 30 cases of osteosarcoma in the short term was 73.3% (22/30). Adverse reactions mainly included digestive tract discomfort, myelosuppression, hepatic dysfunction and skin and mucosal injury. Conclusion High-dose methotrexate treatment of osteosarcoma has a good effect, but high-dose methotrexate has strong toxicity of chemotherapy drugs, adverse reactions, the patient’s blood concentration needs to be closely monitored and actively deal with various complications to ensure that patients can Smooth chemotherapy.