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探讨应用高危人乳头瘤病毒(HPV)检查和宫颈细胞学检查筛查子宫颈癌及癌前病变的价值及对高危型HPV阳性患者的处理方案。 在英国附属于5个医疗中心的161个社区进行本项研究,研究对象在过去3年内宫颈细胞学检查无异常及未接受宫颈上皮内瘤样病变(CIN)治疗。对研究对象做宫颈细胞学检查和高危型HPV检查。将临界细胞学改变(相当于巴氏IIa或TBS分类ASCUS或AGCUS,译者注)和高危型HPV阳性伴细胞学阴性规定为筛查异常。将筛查异常的患者随机分配到立即阴道镜检查组或随诊组。对随诊者在6个月时进行细
To explore the application of high-risk human papillomavirus (HPV) test and cervical cytology screening of cervical cancer and precancerous lesions of the value and treatment of high-risk HPV-positive patients. The study was conducted in 161 communities affiliated with 5 medical centers in the United Kingdom. Subjects underwent cervical cytology within the last 3 years and were not treated with cervical intraepithelial neoplasia (CIN). Cervical cytology and high-risk HPV tests were performed on the subjects. Critical cytology changes (equivalent to ASCUS or AGCUS for Papanicolaou or TBS classification) and high-risk HPV-positive cytology were defined as screening abnormalities. Patients with abnormal screening were randomized to immediate colposcopy or follow-up. For follow-up at 6 months to fine