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本文报道用人纤维母细胞干扰素(HFIF)治疗2例HBsAg阳性慢性活动性肝炎的效果。HFIF系用胎儿肺成纤维细胞层,经Poly-I-C诱导和放线菌素及D环六酰胺加强诱导而成。例1 57岁,男,1976年1月发现肝肿大伴细小结节,肝活检呈典型慢性活动性肝炎伴早期肝硬化。10个月随访中血清HBsAg持续阳性,HBsAb阴性,e抗原抗体阴性,Dane颗粒极少。除谷草转氨酶轻度升高外肝功能正常。重复肝活检未见改变。例2 22岁,药瘾者。1975年6月患轻型乙型肝炎。肝大伴谷草转氨酶持续升高。同年12月肝活检呈
This article reports the efficacy of human fibroblast interferon (HFIF) in the treatment of 2 HBsAg-positive chronic active hepatitis. HFIF Department of fetal lung fibroblasts, induced by Poly-I-C and actinomycin and D ring six amide induced enhanced. Example 1 57-year-old male, 1976 January hepatomegaly with small nodules, liver biopsy showed typical chronic active hepatitis with early cirrhosis. Serum HBsAg was consistently positive at 10 months of follow-up, HBsAb negative, e antigen antibody negative, Dane particles very few. In addition to mildly elevated transglutaminase liver function is normal. Repeat liver biopsy did not change. Example 2 22 years old, drug addict. June 1975 suffering from mild hepatitis B. Liver with cereal aminotransferase continued to rise. The same year in December liver biopsy was