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目的评估序贯疗法和序贯疗法联合益生菌根除Hp感染的疗效和安全性。方法 360例Hp感染伴消化不良者随机入选序贯疗法组和序贯疗法联合益生菌组,序贯疗法组前5 d予埃索美拉唑+阿莫西林治疗,后5 d予埃索美拉唑+克拉霉素+甲硝唑治疗。序贯疗法联合益生菌组在序贯疗法治疗的基础上每天给予双歧杆菌三联活菌治疗。治疗结束至少停药4周后复查13C尿素呼气试验,结果阴性,表示根除成功。同时评估疗效及安全性。对Hp根除率进行意向性分析和符合方案分析比较。结果按意向性分析,序贯疗法组Hp根除率为81.1%(146/180),加用益生菌组为93.9%(169/180),差异有统计学意义(χ2=13.4,P<0.01);按符合方案分析,序贯疗法组Hp根除率为83.0%(146/176),加用益生菌组为94.9%(169/178),差异有统计学意义(χ2=13.0,P<0.01)。结论加用益生菌治疗可改善序贯疗法根除Hp的疗效。
Objective To evaluate the efficacy and safety of sequential therapy and sequential therapy combined with probiotics in the eradication of Hp infection. Methods 360 cases of Hp infection with dyspepsia were randomly selected sequential therapy group and sequential therapy combined probiotics group, the first 5 days of sequential therapy group to esomeprazole + amoxicillin treatment, after 5 d to Esso-mei Lazole + clarithromycin + metronidazole treatment. Sequential therapy combined with probiotics group was treated with Bifidobacterium triple viable bacteria daily on the basis of sequential therapy. At least 4 weeks after the end of treatment review 13C urea breath test, the result was negative, said the eradication success. At the same time evaluate the efficacy and safety. Hp eradication rate of intention analysis and in accordance with the program analysis and comparison. Results According to the analysis of intentionality, the Hp eradication rate was 81.1% (146/180) in sequential therapy group and 93.9% (169/180) in probiotics group (χ2 = 13.4, P <0.01) According to the protocol analysis, the Hp eradication rate was 83.0% (146/176) in the sequential therapy group and 94.9% (169/178) in the probiotics group (χ2 = 13.0, P <0.01) . Conclusions Adding probiotics can improve the efficacy of sequential therapy in eradicating Hp.