Ⅱ型糖尿病兔大脑皮质和海马神经元的神经丝蛋白表达(英文)

• 作 者: 马志健 刘正清 张秋菊 蔡维君 李明波 刘小丹 陈二云
• 机 构: 中南大学湘雅医学院心血管研究室,中南大学湘雅医学院心血管研究室,Department of Biochemistry,medical college of NanHua University,Heng
• 出 处: 中国医学工程
• 发表日期: 2002年06期
• 关键词: Ⅱ型糖尿病 海马神经元 大脑皮质 神经丝蛋白 neuronal carbohydrate stained Zealand axonal impaired

Objective: To investigate the morphological changes of the neuronal neurites in diabetic rabbitbrain. Methods: Twenty-four New Zealand White rabbits were divided into 2 groupes: control group and type Ⅱdiabetic group induced by high-carbohydrate and high-fat diet. The levels of blood sugar and insulin were detect-ed at week 0(w0), w4, w8, w13, w18, w23 and w28. Brain tissue was stained by Nissl staining and immunohis-tochemistry with a specific antibody to neurofilament proteins. Result: In diabetic rabbits, the amount of large pyra-

Objective: To investigate the morphological changes of the neuronal neurites in diabetic rabbit brain. Methods: Twenty-four New Zealand White rabbits were divided into 2 groupes: control group and type II diabetic group induced by high-carbohydrate and high-fat diet. The levels of Blood sugar and insulin were detected-week at week 0 (w0), w4, w8, w13, w18, w23 and w28. Brain tissue was stained by Nissl staining and immunohis-tochemistry with a specific antibody to neurofilament proteins. rabbits, the amount of large pyra-