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门静脉高压和肝功能损害是引起肝硬化疗效不佳的两个主要并发症,传统药物临床疗效难以令人满意。本研究对阿托伐他汀治疗大鼠胆道结扎肝硬化的作用机制进行探讨。1材料与方法1.1实验动物分组及模型制备健康雄性6~8周SD大鼠,体质量150~180 g(购自中科院上海实验动物中心),60只随机分为假手术组、对照组及阿托伐他汀治疗组。将实验大鼠结扎胆总管,假手术组只显露
Portal hypertension and impaired liver function are the two major complications of poor response to cirrhosis. The clinical efficacy of traditional drugs is not satisfactory. This study was to investigate the mechanism of atorvastatin on biliary cirrhosis in rats. 1 Materials and methods 1.1 Experimental animal grouping and model preparation Healthy male 6 to 8 weeks SD rats, body weight 150 ~ 180 g (purchased from the Shanghai Laboratory Animal Center, Chinese Academy of Sciences), 60 were randomly divided into sham operation group, control group and A Atorvastatin treatment group. Ligation of common bile duct in rats, sham operation group only revealed