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目的 :探讨湖南地区口腔黏膜下纤维性变 (OSF)癌变情况。方法 :对近 2 0年来就诊于湖南数家大医院 1166名OSF病例及其癌变病例进行分析。结果 :1166例OSF患者 ,有 2 0例伴有口腔鳞状细胞癌 ,癌变率为1.7% ,其中男 18例 ,女 2例 ,癌变病例主要来源于湘潭地区 ,均为长期咀嚼槟榔者 ,18例 (90 % )有 15年以上吸烟史 ,癌变部位主要位于颊部 ,患者均存在不同程度的张口受限。另外 ,还有 74例 (6.3 % )伴有口腔白斑 ,3 7例(3 .2 % )伴有口腔扁平苔藓。结论 :OSF是一种与嚼槟榔有关的癌前状态 ,可以出现癌变。
Objective: To investigate the carcinogenesis of oral submucous fibrosis (OSF) in Hunan Province. Methods: A total of 1166 patients with OSF in several major hospitals in Hunan Province in recent 20 years and their cancer patients were analyzed. Results: In 1166 cases of OSF, 20 cases were accompanied with oral squamous cell carcinoma. The rate of carcinogenesis was 1.7%, including 18 males and 2 females. The patients with OSF mainly came from Xiangtan area, all were long-term chewing betel nuts, 18 Cases (90%) had a history of more than 15 years of smoking. The cancerous sites were mainly located in the buccal area, and patients had limited mouth opening to varying degrees. In addition, there are 74 cases (6.3%) accompanied by oral leukoplakia, 37 cases (3.2%) with oral lichen planus. CONCLUSIONS: OSF is a precancerous condition associated with chewing betel nuts that can develop cancerous lesions.