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目的 探讨阴道分泌物中IL-4与IL-12的表达与复发性外阴阴道念珠菌病复发的关系。方法 ELISA法检测复发性外阴阴道念珠菌病(RVVC)患者组、外阴阴道念珠菌病(VVC)患者组阴道中IL-4,IL-12的表达水平,以正常女性白念珠菌携带者为对照组。结果 RVVC组的IL-4水平高于VVC组和对照组,差异有统计学意义(P<0.05),但3组的IL-12水平差异无统计学意义(P>0.05)。结论 IL-4表达差异可能与RVVC复发有关。
Objective To investigate the relationship between the expression of IL-4 and IL-12 in vaginal secretions and the recurrence of recurrent vulvovaginal candidiasis. Methods The levels of IL-4 and IL-12 in the vagina of patients with recurrent vulvovaginal candidiasis (RVVC) and vulvovaginal candidiasis (VVC) were detected by ELISA. The results were compared with those of normal female Candida albicans group. Results The level of IL-4 in RVVC group was significantly higher than that in VVC group and control group (P <0.05). However, the level of IL-12 in RVVC group was not significantly different (P> 0.05). Conclusion The difference of IL-4 expression may be related to RVVC recurrence.