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目的：考核HFRS地鼠肾细胞Ⅱ型灭活疫苗的安全性、免疫法及其流行病学效果。方法：采用间接免疫荧光抗体试验（IFA）、微量细胞变性中和试验（MCPENT），检测接种者血中荧光抗体及中和抗体水平；调查接种组与对照组发病情况。结果：以怀宁、广德两县18个村为疫苗观察现场，接种组7499人，对照组7261人，中强反应率为224％（5／223）。3针全程免疫后中和抗体阳转率为63．33％（19／30），荧光抗体阳转率为38.58％（27／70）；接种后1年内接种组无发病，对照组发病3例。结论：该疫苗的安全性较好；有一定水平的免疫应答，但防病效果应进一步观察确证。
Objective: To evaluate the safety, immunological methods and epidemiological effects of type Ⅱ inactivated HFRS hamster kidney cell vaccine. Methods: IFA and MCPENT were used to detect the level of fluorescent antibody and neutralizing antibody in the blood of vaccinated children. The incidence of inoculation and control groups was investigated. Results: In Huaining and Guangde counties, 18 villages were vaccinated. There were 7499 inoculation group and 7261 in control group. The moderate to strong response rate was 224% (5/223). The positive rate of neutralizing antibody was 63.33% (19/30) and the positive rate of fluorescent antibody was 38.58% (27/70) after 3-needle whole-body immunization. There was no incidence of inoculation in 1 year after inoculation and 3 cases in control group . Conclusion: The vaccine is safe and has a certain level of immune response, but its effect should be further confirmed.